Biomaterials in Medicine and Dentistry

• Biomedical Engineering, Semester 2, position 5

Introducing students to the application of different biomaterials, previously discussed during Foundations of Biomaterials course, in order to understand and study functional behaviour of biomaterials in the human body. Analysis of the connections between the biomaterial and the body system, in order to ensure reliable implant operation. The potential co-operation with experts in the field of materials science, dentistry and medicine is allowed, which provides the ability to work in specialized laboratories and clinical facilities.

By attending this course the student will master the application of biomaterials in medicine and dentistry, using modern scientific methods. Theoretical considerations, laboratory experimental work and the application of numerical analysis using the licensed software for finite element method, enables the synergy of the previously acquired knowledge in physics, materials science, mathematics and mechanics, in order to implement them in engineering practice.

Application of biomaterials in medicine and dentistry. Fundamentals of making implants in the human body. Compounding biomaterials and achieving biocompatibility. Problems of contact surfaces in designing the structure of biomaterials in the human body. The problems of various physical, chemical and mechanical properties of combined materials. Damage of biomaterials during the exploitation: wear, corrosion and fatigue of biomaterials, corrosion under stress, cracking. Biocomposite materials; achieving a gradual change in material properties in the compound (functionally graded materials FGM). Thin coatings and nanostructured biomaterials. New alloys in biomedical applications. Testing of biomaterials. Lifetime and structural integrity assurance of biomaterials: analytical, numerical and experimental methods. Prevention of failure of the biomaterials structure (case studies).

Examples of applications of biomaterials in the design, development and exploitation of structures used in medicine and dentistry. Examples and solutions of implants that are made from biomaterials. Experimental Methods In Vitro and In Vivo. Application of analytical and numerical models in the structural integrity assurance of biomaterials. Development of a model using the finite element method. Calculation examples considering problems in designing connecting surfaces in biomaterial structures. Application of configuration forces method to prevent failure of the biomaterials structures.

required: Biomaterials Basics; desirable: Basics of biomedical engineering and Biophysics

[1] Written lessons from lectures (handouts) [2] A. Sedmak, M. Rakin, Biomaterials - compounds and problems of the connecting surfaces, Belgrade 2011 (script in preparation) [3] T. Nenadovic, Stainless Materials, BIGZ, Belgrade, 2001 [4] ABAQUS User's Manuals, Hibbit, Karlsson & Sorensen, Abaqus Inc., Version 6.5 and upgrades 2005-2007

Total assigned hours: 75

New material: 20
Elaboration and examples (recapitulation): 10

Auditory exercises: 10
Laboratory exercises: 8
Calculation tasks: 5
Seminar paper: 0
Project: 4
Consultations: 0
Discussion/workshop: 3
Research study work: 0

Review and grading of calculation tasks: 0
Review and grading of lab reports: 3
Review and grading of seminar papers: 0
Review and grading of the project: 4
Test: 2
Test: 1
Final exam: 5

Activity during lectures: 10
Test/test: 20
Laboratory practice: 20
Calculation tasks: 0
Seminar paper: 0
Project: 20
Final exam: 30
Requirement for taking the exam (required number of points): 40

J.B. Park and R.S. Lakes. Biomaterials An Introduction. Plenum Press, New York, 1992.; I.Milne, R.O. Ritcie, B. Karihaloo. Comprehensive Structural Integrity, Vol. 9: Bioengineering. Elsevier Ltd, Oxford, 2003.; D. M. Brunette, P. Tengvall, M. Textor, P. Thomsen, Titanium in Medicine, Springer, Berlin, 2001.; T.L. Anderson, Fracture Mechanics: Fundamentals and Applications 3rd ed. CRC Press, London, 2005.; M. Kоjić, N. Filopović, B. Stojanović, N. Kojić, Computer Modeling in Bioengineering. John Wiley and Sons, Ltd (2008)