• Biomedical Engineering, Semester 3, position 3

Тhe student will master the knowledge in the field of nanoscience and the application of nanotechnology in medicine, with a special focus on laboratory work in the characterization of biomaterials using nanotechnological methods, techniques, and instrumentation. The student will acquire knowledge of modern diagnostic and therapeutic nanotechnological methods in medicine and will be trained to prepare classical and biological samples in collaboration with medical staff and to characterize them using nanotechnological instrumentation.

Upon successful completion of this course, students should be able to: • Distinguish the operating principles and specific application conditions of devices based on nanotechnology in medicine • Recognize the advantages of applying new nanotechnology-based devices in medicine compared to classical ones • Propose modifications to technical solutions in nanotechnology to facilitate their more effective application in medicine • Write and present a scientific paper in accordance with professional standards, with a presentation quality equal to that of works published in professional journals

A Brief History of Medicine: From the origins of mankind to Asclepius. From Asclepius to Hippocrates. Then from Hippocrates to the healers of the Middle Ages. From these healers to van Leeuwenhoek. From van Leeuwenhoek to the discovery of DNA. From DNA to quantum medicine. From quantum medicine to nanomedicine. Basics of Molecular Medicine: Classical medical approach to diseases. Drug absorption, distribution, metabolism, and excretion (ADME). Molecular basics of diseases. Basics of molecular nanotechnology and its applications in medicine. Basics of Nanomedicine: Nanoparticles and nanomaterials in medicine. Quantum dots made from semiconducting nanoparticles. Fullerene-based quantum dots. Attachment of hydroxyl groups and other molecules to base nanomaterials. Use of AFM for measuring intermolecular forces. Nanotechnology and Nanobiomedicine: Comparison of the use of classical and nanotechnological methods and techniques used in diagnostics and treatment. Advantages and risks of using nanoparticles in medicine. Nanosensors: Nanosensors for electrical, electrochemical, and optical measurements. Nanotechnology in Pharmacy: Possibilities and scope of nanopharmacy. Production (synthesis) of nanoparticles. Biological barriers. Pharmaceutical nanosystems engineering. Smart drug delivery systems. Nanotechnology in Implantology. Biocompatibility of Nanomedical Materials: Biocompatibility of coated diamond materials. Biocompatibility of fullerenes and carbon nanotubes. Biocompatibility of fluorocarbon polymers.

UV-Vis-NIR,FTIR spectroscopy; Nanotechnological characterization:STM, AFM and MFM; Biocompatibility of nanomaterials; Toxicity of nanomaterials and nanoparticles.

Fractal Mechanics, Introduction to Nanotechnology, Signal processing, Nanotechnology

Teaching materials for each unit (handouts), and access to the NanoLab laboratory, which includes: a NanoProbe device with STM/AFM/MFM capability, a thin (nano) film deposition system, a UV/VIS/NIR spectrophotometer, an FTIR spectrometer, and an optical microscope.

Total assigned hours: 75

New material: 20
Elaboration and examples (recapitulation): 10

Auditory exercises: 20
Laboratory exercises: 5
Calculation tasks: 0
Seminar paper: 5
Project: 0
Consultations: 0
Discussion/workshop: 0
Research study work: 0

Review and grading of calculation tasks: 0
Review and grading of lab reports: 0
Review and grading of seminar papers: 5
Review and grading of the project: 0
Test: 5
Test: 0
Final exam: 5

Activity during lectures: 5
Test/test: 40
Laboratory practice: 0
Calculation tasks: 0
Seminar paper: 25
Project: 0
Final exam: 30
Requirement for taking the exam (required number of points): 40

Sharma, Abhinay, et al., eds. Nanosensors in Healthcare Diagnostics. Elsevier, 2024. eBook ISBN: 9780443153099; Webster, Thomas J., ed. Nanomedicine: Technologies and applications. Woodhead Publishing, 2023. eBook ISBN: 9780128193013; Jain, K.K., The Handbook of Nanomedicine, Third Edition, Humana Press, New York, NY. 2017. eBook ISBN 978-1-4939-6966-1; Wiesner, Mark R., Jean-Yves Bottero. Environmental nanotechnology: applications and impacts of nanomaterials. McGraw-Hill Education, 2017. ISBN: 9780071477505 ; Bawa, Raj, Gerald F. Audette, Israel Rubinstein, eds. Handbook of clinical nanomedicine: nanoparticles, imaging, therapy, and clinical applications. Vol. 1. CRC Press, 2016. eBook ISBN9780429068287